1,25-dihydroxyvitamin D Regulation of von Hippel-Lindau (VHL) and ProlylHydroxylase 2 (PHD2) in MCF10A Breast Epithelial Cells Containing the Harvey-Ras-Oncogene
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1,25-Dihydroxyvitamin D Alters Lipid Metabolism And Epithelialto- Mesenchymal Transition In Metastatic Epithelial Breast Cancer Cells
Barnard, Alle N. M.S., Purdue University, August 2014. 1,25-dihydroxyvitamin D alters lipid metabolism and epithelial-to-mesenchymal transition in metastatic epithelial breast cancer cells. Major Professor: Dorothy Teegarden. Evidence suggests that high vitamin D status (marked by serum 25hydroxyvitamin D, 25(OH)2D) is associated with a decreased risk of breast cancer. It has been established t...
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Mutations or loss of both alleles of the von Hippel-Lindau (VHL) tumor suppressor gene has been documented in sporadic renal cell carcinomas and neoplasms that arise in individuals having the VHL syndrome. The well-vascularized phenotype of tumors that form in VHL disease let us consider vascular endothelial growth factor (VEGF) as a mediator of tumor growth in VHL disease. Human renal carcinom...
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The molecular basis of the erythrocytosis group of red cell disorders is incompletely defined. Some cases are due to dysregulation of erythropoietin (Epo) synthesis. The hypoxia inducible transcription factor (HIF) tightly regulates Epo synthesis. HIF in turn is regulated through its alpha subunit, which under normoxic conditions is hydroxylated on specific prolines and targeted for degradation...
متن کاملThe expression of the von Hippel-Lindau gene product and its impact on invasiveness of human breast cancer cells.
The von Hippel-Lindau (VHL) gene is located on the short arm of chromosome 3, the mutations of which lead to the development of von Hippel-Lindau disease. The VHL gene is a putative tumour suppressor gene in VHL and a few other conditions, possibly by negative regulation of hypoxia- inducible factor-1 (HIF-1) and the stromal-derived factor-1 (SDF-1) receptor, CXCR4, via which the VHL protein ne...
متن کاملGene Expression and Promoter Methylation Status of VHL, Runx-3, E-cadherin, P15 and P16 Genes During EPO-Mediated Erythroid Differentiation of CD34+ Hematopoietic Stem Cells
Background: VHL (von Hippel-Lindau), Runx-3 (Runt-related transcription factor 3), E-cadherin (Epithelial cadherin), P15 (INK4a, cyclin dependent kinase inhibitor), and P16 (INK4b) genes are essential in hematopoiesis. The aim of this study was to explore the correlation between gene expression and promoter methylation in CD34+ stem cells before and after differentiation to erythroid lineage. M...
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تاریخ انتشار 2013